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Dr. David Wilson
 
  Dr. David Wilson  

The ability to make appropriate associations between actions and outcomes (operant conditioning) is a central component to an organism’s survival. I wish to understand how neurons in different, but connected, parts of the brain allow this process to happen. Previously, I have recorded from single nucleus accumbens neurons and midbrain dopamine neurons during operant conditioning tasks (see publications below). In this project I am keen to understand how neurons in parts of the pedunculopontine tegmental nucleus (PPTg) that project differentially to midbrain dopamine neurons are involved in this learning process and whether they are essential to it. I have additional interests in the potential functions of cortico-basal ganglia architecture, such as classical conditioning, motivation, action selection, and decision-making.

arrow_ indicating_link digw@st-andrews.ac.uk Tel: +44 (0)1334 46 2060
   
Wilson, D.I. and Bowman, E.M. (2006) Neurons in dopamine-rich areas of the rat medial midbrain predominantly encode the outcome-related rather than behavioral-switching properties of conditioned stimuli. European Journal of Neuroscience 23:205-218.
Wilson, D.I. and Bowman, E.M. (2005) Rat nucleus accumbens neurons predominantly respond to the outcome-related properties of conditioned stimuli rather than their behavioral-switching properties. Journal of Neurophysiology 98:918-929.
Wilson, D.I. and Bowman, E.M. (2004) Nucleus accumbens neurons in the rat exhibit differential activity to conditioned reinforcers and primary reinforcers within a second-order schedule of saccharin reinforcement. European Journal of Neuroscience 20:2777-2788.
Wilson, D.I. and Bowman, E.M. (2004) Second-order stimuli do not always increase overall response rates in second-order schedules of reinforcement in the rat. Psychopharmacology (Berl) 174(3):430-7.
 
 

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