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I am currently working with Professor Verity Brown on projects funded by Organon Research Scotland. My research involves the investigation of stimulus-response formation, and the processes involved in maintaining and/or altering responses based on changing conditions – cognitive flexibility and rigidity. Use of such measures in understanding cognitive/behavioural impairments in conditions such as schizophrenia and rodent models thereof presents an opportunity for exploring novel treatments for these disorders, as well as allowing greater awareness of the nature of these processes in the normal condition.
I have focussed on the prefrontal cortex and connected areas of the brain, notably the basal forebrain – using attentional set-shifting and reversal learning tasks to investigate the formation, maintenance and shifting of attentional set, and reversals of stimulus-response associations.
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 dst@st-andrews.ac.uk |
Tel: +44 (0)1334 46 2088 |
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| Tait, D.S. and Brown, V.J. (2008) Lesions of the basal forebrain impair reversal learning but not shifting of attentional set in rats, Behavioural Brain Research, 187: 100-8. |
| Tait, D.S. and Brown, V.J. (2007) Difficulty Overcoming Learned Non-reward during Reversal Learning in Rats with Ibotenic Acid Lesions of Orbital Prefrontal Cortex, Annals of the New York Academy of Sciences, 1121: 407-20. |
| Tait, D.S., Brown, V.J., Farovik, A., Theobald, D.E., Dalley, J.W. and Robbins, T.W. (2007) Lesions of the dorsal noradrenergic bundle impair attentional set-shifting in the rat, European Journal of Neuroscience, 25: 3719-24. |
| Hatcher, P.D., Brown, V.J., Tait, D.S., Bate, S., Overend, P., Hagan, J.J. and Jones, D.N. (2005) 5-HT6 receptor antagonists improve performance in an attentional set shifting task in rats, Psychopharmacology (Berl), 181: 253-9. |
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